Bioinformatics-based identification of key candidate genes and signaling pathways in patients with Parkinson ’s disease and obstructive sleep apnea

ConclusionOur findings suggest that CADPS, CHGA, and SCG3 are key genes involved in molecular mechanisms underlying interactions between OSA and PD. Functional enrichment of hub genes indicated a link between GABAergic synapses and the shared pathogenesis of PD and OSA. These candidate genes and corresponding pathways offer novel insights regarding biological targets that underlie the transcriptional connection between OSA and PD.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research