Association of Somatic TET2 Mutations With Giant Cell Arteritis

ConclusionsCH increases risk for development of GCA in a genotype-specific manner, with the greatest risk being conferred by the presence of mutations inTET2. SomaticTET2 mutations likewise increase the risk of GCA-associated vision loss. Integration of somatic genetic testing in GCA diagnostics may be warranted in the future.

Source: Arthritis and Rheumatology - February 3, 2024 Category: Rheumatology Authors: Michelle L. Robinette, Lachelle D. Weeks, Ryan J. Kramer, Mridul Agrawal, Christopher J. Gibson, Zhi Yu, Aswin Sekar, Arnav Mehta, Abhishek Niroula, Jared T. Brown, Gregory C. McDermott, Edith R. Reshef, Jonathan E. Lu, Victor D. Liou, Carol Tags: Brief Report Source Type: research