Association of a novel frameshift variant and a known deleterious variant in MMR genes with Lynch syndrome in Chinese families

Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome. This condition is characterized by germline variants in DNA mismatch repair (MMR) genes, including MLH1, MSH2, MSH6, and PMS2. I...

Source: World Journal of Surgical Oncology - January 27, 2024 Category: Cancer & Oncology Authors: Juyi Li, Haichun Ni, Xiufang Wang, Wenzhuo Cheng, Li Li, Yong Cheng, Chao Liu, Yuanyuan Li and Aiping Deng Tags: Research Source Type: research