Physiologic Homeostasis after Pig-to-Human Kidney Xenotransplantation
Demand for kidney grafts outpaces supply, limiting kidney transplantation as a treatment for kidney failure. Xenotransplantation has the potential to make kidney transplantation available to many more patients with kidney failure, but the ability of xenografts to support human physiologic homeostasis has not been established. A brain-dead adult decedent underwent bilateral native nephrectomies followed by 10 gene-edited (four gene knockouts, six human transgenes) pig-to-human xenotransplantation.
Source: Kidney International - Category: Urology & Nephrology Authors: Eric Judd, Vineeta Kumar, Paige M. Porrett, Kelly A. Hyndman, Douglas Anderson, Maggie Jones-Carr, Andrew Shunk, Daniel R. Epstein, Huma Fatima, Akemi Katsurada, Ryousuke Satou, L. Gabriel Navar, Jayme E. Locke Tags: landmark communication Source Type: research
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