Factors influencing methotrexate pharmacokinetics highlight the need for individualized dose adjustment: a systematic review

ConclusionsMethotrexate dosage regimens were primarily based on body surface area and renal function. Further studies are needed to evaluate MTX pharmacokinetics and pharmacodynamics in both children (especially infants) and adults.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research