Performance of 99mTc-PYP scintigraphy in the diagnosis of hereditary transthyretin cardiac amyloidosis

ConclusionsAla97Ser is the most common genotype in ATTRv-CA in our cohort, with characteristics of later onset and rapid progression, but delayed diagnosis and extensive99mTc-PYP uptake. Overall, ATTRv-CA patients showed moderate-to-extensive myocardial99mTc-PYP uptake. Additionally, VGS carries subjectivity, low specialty and interobserver consistency. But H/CL exhibit high diagnostic efficacy and interobserver consistency. The H/CL ratio is more useful than VGS.
Source: Annals of Nuclear Medicine - Category: Nuclear Medicine Source Type: research