Efficacy of short-course treatment for prevention of congenital transmission of Chagas disease: A retrospective cohort study

by Guillermo Moscatelli, Samanta Moroni, Juan Carlos Ram írez, Belén Warszatska, Lascano Fernanda, Nicolás González, Andrés Rabinovich, Jaime Altcheh BackgroundIn regions with controlled vector transmission ofT.cruzi, congenital transmission is the most frequent route of infection. Treatment with benznidazole (BZ) or nifurtimox (NF) for 60 days in girls and women of childbearing age showed to be effective in preventing mother to child transmission of this disease. Reports on short-course treatment ( ≤30 days) are scarce. MethodsRetrospective cohort study. Offspring of women with Chagas disease who received short-course treatment ( ≤30 days) with BZ or NF, attended between 2003 and 2022, were evaluated. Parasitemia (microhaematocrit and/or PCR) was performed at
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research