Age, BMI, and Type 2 Diabetes Modify the Relationship Between PNPLA3 and Advanced Fibrosis in Children and Adults With NAFLD

PNPLA3 G-allele is an important determinant of disease severity in nonalcoholic fatty liver disease (NAFLD). Here, we investigated the effect of age, body mass index (BMI), and type 2 diabetes mellitus (T2DM) on the relationship between PNPLA3 G-allele and advanced fibrosis in adults and children with histologically characterized NAFLD.

https://www.cghjournal.org/article/S1542-3565(23)01041-8/fulltext?rss=yes

Source: Clinical Gastroenterology and Hepatology - December 23, 2023 Category: Gastroenterology Authors: Chaowapong Jarasvaraparn, Eduardo Vilar-Gomez, Katherine P. Yates, Laura A. Wilson, Brent Neuschwander-Tetri, Rohit Loomba, Oscar Cummings, Miriam Vos, Stavra Xanthakos, Jeffrey Schwimmer, Jean P. Molleston, Arun Sanyal, James Tonascia, Naga Chalasani Source Type: research