Oxygen glucose deprivation-pretreated astrocyte-derived exosomes attenuates intracerebral hemorrhage (ICH)-induced BBB disruption through miR-27a-3p /ARHGAP25/Wnt/ β-catenin axis

ConclusionTaken together, these findings firstly revealed that miR-27a-3p, as one of the main components of OGD-pretreated ADEVs, attenuated BBB destruction and improved neurological deficits following ICH by regulating endothelial ARHGAP25/Wnt/ β-catenin axis. OGD-ADEVs might be a novel strategy for the treatment of ICH.this study implicates that EVs from OGD pre-stimulated astrocytes.Graphical Abstract
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research