Interferon ‐regulatory factor‐1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14‐3‐3γ axis

ConclusionThe IRF1-mediated VEGFA/14-3-3 γ signalling pathway promotes BVZ-induced myocardial injury. Our study provides evidence for potentially new target genes for the treatment of myocardial injury.

Source: ESC Heart Failure - January 18, 2024 Category: Cardiology Authors: Xuan ‐Ying Chen, Meng‐Qi Xie, Wei‐Lin Huang, Wen‐Juan Li, Yan‐Ni Lv, Xiao‐Ping Peng Tags: Original Article Source Type: research