Free-water diffusion magnetic resonance imaging under selegiline treatment in Parkinson's disease

Monoamine oxidase type B inhibitors, including selegiline, are established as anti-Parkinsonian Drugs. Inhibition of monoamine oxidase type B enzymes might suppress the inflammation because of inhibition to generate reactive oxygen species. However, its effect on brain microstructure remains unclear. The aim of this study is to elucidate white matter and substantia nigra (SN) microstructural differences between Patients with Parkinson's disease with and without selegiline treatment by two independently recruited cohorts.

Source: Journal of the Neurological Sciences - January 13, 2024 Category: Neurology Authors: Haruka Takeshige-Amano, Taku Hatano, Koji Kamagata, Christina Andica, Takashi Ogawa, Atsuhiko Shindo, Wataru Uchida, Wataru Sako, Shinji Saiki, Yasushi Shimo, Genko Oyama, Atsushi Umemura, Masanobu Ito, Masaaki Hori, Shigeki Aoki, Nobutaka Hattori Source Type: research