Progression of type 1 diabetes is associated with high levels of soluble PD-1 in islet autoantibody-positive children

Conclusions/interpretationThis study reveals an sICM profile that is dysregulated during the preclinical stage of type 1 diabetes, and identifies sPD-1 as a pathophysiologically-relevant molecule that is associated with disease progression, offering a potential target for early interventions in autoimmune diabetes.Graphical Abstract
Source: Diabetologia - Category: Endocrinology Source Type: research