Deficiency of TOP1MT enhances glycolysis through the stimulation of PDK4 expression in gastric cancer

ConclusionsIn brief, our work demonstrated the critical function of TOP1MT in the regulation of glycolysis by PDK4 in gastric cancer. Inhibiting glycolysis and limiting tumor metastasis in GC may be accomplished by suppressing PDK4.

Source: Cancer and Metabolism - January 10, 2024 Category: Cancer & Oncology Source Type: research