Expression profiles of the lncRNA antisense GAS5-AS1 in colon biopsies from pediatric inflammatory bowel disease patients and its role in regulating sense transcript GAS5

Conclusion: This study provided for the first time new insights into the potential role of GAS5-AS1 in IBD. GAS5-AS1 modulates GAS5 levels in vitro and may serve as a potential IBD diagnostic biomarker.What is Known:• GAS5 is involved in regulating intestinal MMP-2 and MMP-9 in pediatric patients with IBD;• GAS5-AS1 has never been investigated in the context of IBD;• GAS5-AS1 regulates the expression of GAS5, increasing its stability in tissues and in vitro cell models of cancer.What is New:• GAS5-AS1 correlated with GAS5 and IBD clinical parameters;• GAS5-AS1 can modulate GAS5 levels in macrophages;• GAS5-AS1 may serve as potential IBD diagnostic biomarker.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research