Viral Airway Injury Promotes Cell Engraftment in an In Vitro Model of Cystic Fibrosis Cell Therapy

We examined competition dynamics by time-lapse confocal imaging and found that delivered cells accelerate airway regeneration by incorporating into the epithelium. Irradiating the repairing epithelium granted engrafting cells a competitive advantage by diminishing resident stem cell proliferation. Intentionally causing severe injury to the lungs of people with CF would be dangerous. However, naturally occurring events like viral infection can induce similar epithelial damage with patches of denuded epithelium. We found that viral preconditioning promoted effective engraftment of cells primed for viral resistance.PMID:38150545 | DOI:10.1152/ajplung.00421.2022

Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - December 27, 2023 Category: Cytology Authors: Rhianna E Lee Teresa M Mascenik Sidra C Major Jacob R Galiger Emily Bulik-Sullivan Priscila F Siesser Catherine A Lewis James E Bear Jake A Le Suer Finn J Hawkins Raymond J Pickles Scott H Randell Source Type: research