PZR suppresses innate immune response to RNA viral infection by inhibiting MAVS activation in interferon signaling mediated by RIG-I and MDA5

In conclusion, PZR and SHP2 suppress innate immune response to RNA viral infection through inhibiting MAVS activation. This study reveals the regulatory mechanism of PZR-SHP2-MAVS signal axis on IFN signaling mediated by RIG-I and MDA5, which may provide new sight for developing antiviral drugs.PMID:38185222 | DOI:10.1016/j.antiviral.2024.105797

Source: Antiviral Research - January 7, 2024 Category: Virology Authors: Rilin Deng Lini Zhang Shengwen Chen Xinran Li Binbin Xue Huiyi Li Yan Xu Renyun Tian Qian Liu Luoling Wang Shun Liu Di Yang Penghui Li Songqing Tanga Haizhen Zhu Source Type: research