Factor IX administration in the skin primes inhibitor formation and sensitizes hemophilia B mice to systemic factor IX administration

CONCLUSION: Intradermal FIX administration is highly immunogenic, suggesting that the skin compartment is not amenable to immune tolerance induction or therapeutic delivery of clotting factors.PMID:38193070 | PMC:PMC10772885 | DOI:10.1016/j.rpth.2023.102248

Source: Thrombosis and Haemostasis - January 9, 2024 Category: Hematology Authors: Alexandra Sherman Thais B Bertolini Sreevani Arisa Roland W Herzog Radoslaw Kaczmarek Source Type: research