Polyketide synthases mutation in tuberculosis transmission revealed by whole genomic sequence, China, 2011 –2019

Conclusion: Overall, this study provides new insights into the function of PKS and its localization in M. tuberculosis. The study found that ppsA, pks12, and pks13 may contribute to disease progression and higher transmission of certain strains. We also discussed the prospective use of mutant ppsA, pks12, and pks13 genes as drug targets.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research