Alzheimer's disease-associated P460L variant of EphA1 dysregulates receptor activity and blood-brain barrier function

DISCUSSION: These findings suggest that P460L alters EphA1-dependent forward and reverse signaling, which may impact blood-brain barrier function in LOAD.HIGHLIGHTS: EphA1-dependent reverse signaling controls recruitment of T cells by brain endothelial cells. EphA1-dependent reverse signaling remodels brain endothelial cell contacts. LOAD-associated P460L variant of EphA1 shows reduced membrane expression and reduced ligand responses. LOAD-associated P460L variant of EphA1 fails to reverse signal to brain endothelial cells.PMID:38184788 | DOI:10.1002/alz.13603

Source: The Journal of Alzheimers Association - January 7, 2024 Category: Psychiatry Authors: Helen A Owens Lauren E Thorburn Elisabeth Walsby Owen R Moon Pierre Rizkallah Subuhi Sherwani Caroline L Tinsley Louise Rogers Camilla Cerutti Anne J Ridley Julie Williams Vera Kn äuper Ann Ager Source Type: research