Are current regulatory log K < sub > ow < /sub > cut-off values fit-for-purpose as a screening tool for bioaccumulation potential in aquatic organisms?

In this study, the experimentally determined log Kow and fish bioconcentration factors (BCF) of 532 chemicals were compared. While the analysis underlined the robustness of using log Kow as a screening tool (5/532 were false negatives; log Kow: non-bioaccumulative, but BCF: bioaccumulative), it also demonstrated the conservatism of the cut-offs used worldwide. Indeed, many chemicals were deemed potentially Bioaccumulative based on log Kow when a fish bioaccumulation test showed no concern (false positives), therefore, leading to unnecessary use of vertebrate animals. Our analysis shows that the log Kow cut-off could be increased to 4.5 in all regions for all purposes without leading to a reduced protection of humans and the environment.PMID:38158033 | DOI:10.1016/j.yrtph.2023.105556
Source: Regulatory Toxicology and Pharmacology : RTP - Category: Toxicology Authors: Source Type: research