Changes in gut microbiota and lactose intolerance symptoms before and after daily lactose supplementation in individuals with the lactase non-persistent genotype

CONCLUSIONS: Increased levels of Bifidobacterium indicate an adaptation of the gut microbiota upon repetitive consumption of incremental doses of lactose, which was well-tolerated as demonstrated by reduced expired hydrogen levels during the second 25g lactose HBT. Bifidobacteria metabolize lactose without gas production thereby potentially reducing intestinal gas formation in the gut of individuals with the LNP-genotype. This increased lactose tolerance possibly lifts the necessity to remove nutrient-rich dairy foods completely from the diet.REGISTRATION NUMBER OF CLINICAL TRIAL: The trial is registered at the International Clinical Trials Registry Platform: NL9516 The effect of dietary lactose in lactase non-persistent individuals on gut microbiota.PMID:38159728 | DOI:10.1016/j.ajcnut.2023.12.016

Source: Am J Clin Nutr - December 30, 2023 Category: Nutrition Authors: Lonneke JanssenDuijghuijsen Ellen Looijesteijn Maartje van den Belt Beatrix Gerhard Martin Ziegler Renata Ariens Reina Tjoelker Jan Geurts Source Type: research