Evolution of techniques and tools for replication fork proteome and protein interaction studies

This article provides an overview of MS techniques and their applications in proteomics studies, with a focus on the replication fork proteome. The replication fork is a multi-protein assembly involved in DNA replication, and its proper functioning is crucial for maintaining genomic integrity. By combining quantitative MS labeling techniques with various data acquisition methods, researchers have made significant strides in elucidating the complex processes and molecular mechanisms at the replication fork. Overall, MS has revolutionized our understanding of protein dynamics, offering valuable insights into cellular processes and potential targets for therapeutic interventions.PMID:38113480 | DOI:10.1139/bcb-2023-0215
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Source Type: research