AKT2 inhibition accelerates the acquisition of phagocytic ability in induced pluripotent stem cell –derived neutrophils

Neutrophils act as the first-line immune players during bacterial infections. Typically, the first leukocytes recruited to inflammatory sites protect humans from pathogens [1]. Despite recent progress in antibacterial and antifungal therapies, the strategy for dealing with the risk of severe infections associated with prolonged neutropenia caused by chemotherapy, radiotherapy, cancer, or hematologic diseases needs to be further explored [2 –4]. Some reports demonstrated that the use of granulocyte transfusions (GTX) prevented life-threatening infections in patients with neutropenia induced by chemotherapy or hematopoietic stem cell transplantation, but only when high-dose granulocyte transfusions (no less than 0.6 × 109 granulo cytes/kg) were performed [5].

Source: Experimental Hematology - December 13, 2023 Category: Hematology Authors: Toshiya Hino, Fumio Nakahara, Masashi Miyauchi, Yusuke Ito, Yosuke Masamoto, Ken Morita, Yuki Kagoya, Hirotatsu Kojima, Mineo Kurokawa Tags: Brief communication Source Type: research