Regulation of thyroid hormone gatekeepers by TSH in tanycytes

CONCLUSIONS: This study demonstrates that, TSH induces transcriptional regulation of TH gatekeeper genes in tanycytes through the Tshr/Gαq/PKC pathway, in parallel to the Tshr/Gαs/PKA/CREB pathway. These differential actions of TSH on tanycytic subpopulations appear to be important for coordinating the supply of TH to the hypothalamus and aid its functions.PMID:38115594 | DOI:10.1089/thy.2023.0375
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Authors: Source Type: research