Association between Dietary Antioxidants intake and the Risk of Type 2 Diabetes Mellitus in a Prospective Cohort Study: Tehran Lipid and Glucose Study

Br J Nutr. 2023 Dec 20:1-24. doi: 10.1017/S0007114523002854. Online ahead of print.ABSTRACTThe present prospective cohort study aimed to determine whether dietary antioxidants were associated with incident type 2 diabetes mellitus (T2DM). Another objective was to find out whether such associations could be modified by the body mass index (BMI) status. A total of 2188 Tehranian adults aged 21-84 years, free of T2DM with the validated Food Frequency Questionnaire was entered in the study. Multivariable Cox proportional hazards models adjusting for confounders were used to assess the association between dietary antioxidants and incident T2DM in total population, as well as in subjects with various BMI statuses. During 8.9 (8.1-9.6) years of follow-up, dietary vitamin E significantly decreased the incident T2DM, after adjustment for confounders. However, other dietary antioxidants were not shown to be significantly associated with incident T2DM. The interaction between dietary vitamin E, magnesium (Mg) and BMI status was found to influence the risk of T2DM (P for interaction<0.05). After stratification of subjects based on BMI status, it was found that vitamin E and Mg decreased the risk of T2DM only among normal weight individual. Also, an inverse association was found among dietary vitamin C, dietary zinc (Zn), and the risk of T2DM in individuals with normal weight but not in overweight and obese individuals; however, the interaction test tended to be significant for these d...
Source: The British Journal of Nutrition - Category: Nutrition Authors: Source Type: research