Megalencephalic leukoencephalopathy with subcortical cysts protein-1: A new calcium-sensitive protein functionally activated by endoplasmic reticulum calcium release and calmodulin binding in astrocytes

CONCLUSION: Overall, we qualified MLC1 as a Ca2+ sensitive protein involved in the control of volume changes in response to ER Ca2+ release and astrocyte activation. These findings provide new insights for the comprehension of the molecular mechanisms underlining brain edema and myelin degeneration characterizing MLC and other LD where astrocytes have a primary role in the pathological process.PMID:38141856 | DOI:10.1016/j.nbd.2023.106388

Source: Neurobiology of Disease - December 23, 2023 Category: Neurology Authors: M S Brignone A Lanciotti P Molinari C Mallozzi C De Nuccio E S Caprini T C Petrucci S Visentin E Ambrosini Source Type: research