MCPIP1 controls effects of myeloid cells on skin carcinogenesis and hair growth

Monocyte chemotactic protein-induced protein-1 (MCPIP1), or Regnase-1, is an RNase with anti-inflammatory properties (Matsushita et al. 2009). Expression of MCPIP1, encoded by the gene ZC3H12A, is impaired in several types of cancer (Miekus et al. 2019). As the immune system is a key element in the etiology of cancers, we hypothesized that MCPIP1 of myeloid cells is important in the crosstalk between the immune system and cells of developing tumors. To test this hypothesis, we used mice lacking Mcpip1 in cells of myeloid origin (Mcpip1MKO), including macrophages and granulocytes, in a chemical carcinogenesis model of epithelial skin cancer.

Source: Journal of Investigative Dermatology - December 26, 2023 Category: Dermatology Authors: Weronika Szukala, Izabela Rumienczyk, Michal Mikula, Krzysztof Goryca, Leopold Eckhart, Joanna Koziel, Jolanta Jura, Agata Lichawska-Cieslar Tags: Letters to the Editor Source Type: research