Suppression of TRIM19 by arterivirus nonstructural protein 1 promotes viral replication

We report that the numbers of PML NBs per nucleus were significantly downregulated during infection of PRRSV. The overexpression of all six isoforms of PML suppressed the PRRSV replication, and conversely, the silencing of PML gene expression enhanced the PRRSV replication. The suppression of PML NBs by the nsp1 protein was common in other member viruses of the family, represented by equine arteritis virus, lactate dehydrogenase elevating virus of mice, and simian hemorrhagic fever virus. Our study unveils a conserved viral strategy in arteriviruses for innate immune evasion.PMID:38104946 | DOI:10.1016/j.virusres.2023.199302
Source: Virus Research - Category: Virology Authors: Source Type: research