Synthesis and application of bacterial exopolysaccharides

Curr Opin Chem Biol. 2023 Dec 21;78:102418. doi: 10.1016/j.cbpa.2023.102418. Online ahead of print.ABSTRACTExopolysaccharides are produced and excreted by bacteria in the generation of biofilms to provide a protective environment. These polysaccharides are generally generated as heterogeneous polymers of varying length, featuring diverse substitution patterns. To obtain well-defined fragments of these polysaccharides, organic synthesis often is the method of choice, as it allows for full control over chain length and the installation of a pre-determined substitution pattern. This review presents several recent syntheses of exopolysaccharide fragments of Pseudomonas aeruginosa and Staphylococcus aureus and illustrates how these have been used to study biosynthesis enzymes and generate synthetic glycoconjugate vaccines.PMID:38134611 | DOI:10.1016/j.cbpa.2023.102418
Source: Current Opinion in Chemical Biology - Category: Biochemistry Authors: Source Type: research