Reduced Zn < sup > 2+ < /sup > promotes retinal ganglion cells survival and optic nerve regeneration after injury through inhibiting autophagy mediated by ROS/Nrf2

This study verified that TPEN or knocking out ZnT-3 in ACs is a promising therapeutic option for the treatment of optic nerve damage and elucidated the postsynaptic molecular mechanism of Zn2+-triggered damage to RGCs after ONC injury.PMID:38134974 | DOI:10.1016/j.freeradbiomed.2023.12.008

Source: Free Radical Biology and Medicine - December 22, 2023 Category: Biology Authors: Caiqing Wu Jiaxu Han Siting Wu Canying Liu Qi Zhang Jiahui Tang Zhe Liu Jinpeng Yang Yuze Chen Yehong Zhuo Yiqing Li Source Type: research