Test-retest reliability and short-term variability of quantitative light reflex pupillometry in a mixed memory clinic cohort

Quantitative light reflex pupillometry (qLRP) may be a promising digital biomarker in neurodegenerative diseases such as Alzheimer's disease (AD), as neuropathological changes have been found in the midbrain structures governing the light reflex. Studies investigating test-retest reliability and short-term, intra-subject variability of qLRP in these patient groups are missing. Our objective was therefore to investigate the test-retest reliability and short-term, intra-subject variability of qLRP in a memory clinic setting, where patients with neurodegenerative disease are frequently evaluated.

Source: Journal of the Neurological Sciences - December 22, 2023 Category: Neurology Authors: Mathias Holsey Gramkow, Frederikke Kragh Clemmensen, Gunhild Waldemar, Steen Gregers Hasselbalch, Kristian Steen Frederiksen Source Type: research