The value of subcutaneous xenografts for individualised radiotherapy in HNSCC: robust gene signature correlates with radiotherapy outcome in patients and xenografts

CONCLUSION: Genetic prognosticators of outcome for patients after PORT-C and subcutaneous xenografts after primary clinically relevant irradiation show similarity. The identified robust 2-gene signature may help to guide patient stratification, after prospective validation. Thus, xenografts remain a valuable resource for translational research towards the development of individualized radiotherapy.PMID:38109944 | DOI:10.1016/j.radonc.2023.110055

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - December 18, 2023 Category: Radiology Authors: Annett Linge Shivaprasad Patil Marianne Grosser Fabian Lohaus Kristin Gurtner Max Kemper Volker Gudziol Dominik Haim Alexander Nowak Inge Tinhofer Daniel Zips Maja Guberina Martin Stuschke Panagiotis Balermpas Claus R ödel Henning Sch äfer Anca-Ligia Gr Source Type: research