Molecular interactions between perlecan LG3 and the SARS ‐CoV‐2 spike protein receptor binding domain

In this study, we investigated the binding interactions between the SARS-CoV-2 spike protein RBD and perlecan LG3 through molecular modeling simulations and surface plasmon resonance (SPR) experiments. Our results indicate stable binding between LG3 and SARS-CoV-2 spike protein RBD, which may potentially enhance RBD-ACE2 interactions. These findings shed light on the role of perlecan LG3 in SARS-CoV-2 infection and provide insight into SARS-CoV-2 pathophysiology and potential therapeutic strategy for COVID-19.

Source: Protein Science - December 20, 2023 Category: Biochemistry Authors: Timothy E. Gressett, Md Lokman Hossen, Grant Talkington, Milla Volic, Hugo Perez, Purushottam B. Tiwari, Prem Chapagain, Gregory Bix Tags: RESEARCH ARTICLE Source Type: research