Using adipose stem cell spheroids with fibrin hydrogel-assisted delivery for peripheral nerve repair: an experimental study

Introduction: The current treatment options of peripheral nerve injuries, despite substantial advancements, are still unsatisfactory. One promising approach is fibrin-hydrogel nerve conduits (FNCs) loaded with human adipose stem cells (hASCs) for nerve guidance, protection and for local release of neurotrophic factors (TNFs). The combination of FNCs and ASCs showed promising results in vitro and in vivo for nerve regeneration. Within this context, ASCs based spheroids are emerging for enhanced cytokine profile.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Source Type: research