Metabolic reprogramming by Syntenin-1 directs RA FLS and endothelial cell-mediated inflammation and angiogenesis

In conclusion, since the current therapies are ineffective on Syntenin-1 and SDC-1 expression in RA synovial tissue and blood, targeting this pathway and its interconnected metabolic intermediates may provide a novel therapeutic strategy.PMID:38105293 | DOI:10.1038/s41423-023-01108-8

Source: Cellular and Molecular Immunology - December 17, 2023 Category: Molecular Biology Authors: Anja Meyer Stephanie R Zack Wes Nijim Adel Burgos Vishwa Patel Brian Zanotti Michael V Volin M Asif Amin Myles J Lewis Costantino Pitzalis Shiva Arami Joseph A Karam Nadera J Sweiss Shiva Shahrara Source Type: research