Impact of amino acid substitutions in hepatitis C virus core region on the severe oxidative stress

CONCLUSIONS: HCV core proteins harboring either or both substitutions of R70Q/H or L91 M enhanced hepatocellular oxidative stress in vivo and in vitro. These amino acid substitutions may affect HCC development by enhancing hepatic oxidative stress in patients with chronic HCV-1b infection.PMID:38103659 | DOI:10.1016/j.freeradbiomed.2023.12.014

Source: Free Radical Biology and Medicine - December 16, 2023 Category: Biology Authors: Takeshi Chida Shinya Watanabe Kazuyoshi Ohta Hidenao Noritake Masahiko Itoh Tetsuro Suzuki Takafumi Suda Kazuhito Kawata Source Type: research