Modulation of cardio-respiratory activity in mice via transcranial focused ultrasound

The objective of this study was to investigate the effect of FUS on autonomic nervous system activity, including heart and respiratory rates, and to separate the thermal modulation from combined thermal and mechanical FUS effects.Methods: The thalamus and hypothalamus of wild-type mice were sonicated with a continuous-wave, 2 MHz FUS transducer at pressures of 425 and 850 kPa for 60 seconds. Cardiac and respiratory rates were monitored as signs of autonomic nervous activity. FUS-induced changes in autonomic activity were compared to FUS targeted to a spatially-distant motor region and to laser-induced heating.

https://www.umbjournal.org/article/S0301-5629(23)00365-4/fulltext?rss=yes

Source: Ultrasound in Medicine and Biology - December 17, 2023 Category: Radiology Authors: Ethan V. Bendau, Erica P. McCune, Samuel G. Blackman, Hermes A.S. Kamimura, Christian Aurup, Elisa E. Konofagou Tags: Original Contribution Source Type: research