Fructose promotes liver cancer via microbial acetate-induced O-GlcNAcylation

Trends Endocrinol Metab. 2023 Dec 13:S1043-2760(23)00247-3. doi: 10.1016/j.tem.2023.12.002. Online ahead of print.ABSTRACTHigh dietary fructose consumption is linked to multiple disease states, including cancer. Zhou and colleagues recently reported a novel mechanism where high dietary fructose levels increase acetate production by the gut microbiome increasing post-translational modification O-GlcNAcylation in liver cells, which contributes to disease progression in mouse models of hepatocellular carcinoma.PMID:38097465 | DOI:10.1016/j.tem.2023.12.002
Source: Trends in Endocrinology and Metabolism: TEM - Category: Endocrinology Authors: Source Type: research