Isorhamnetin alleviates cisplatin-induced acute kidney injury via enhancing fatty acid oxidation

In conclusion, our findings indicate that isorhamnetin could protect against cisplatin-induced acute kidney injury by inducing PGC-1α-dependent reprogramming of fatty acid oxidation, which highlights the clinical potential of isorhamnetin as a therapeutic approach for the management of cisplatin-induced nephrotoxicity.PMID:38101584 | DOI:10.1016/j.freeradbiomed.2023.12.010

Source: Free Radical Biology and Medicine - December 15, 2023 Category: Biology Authors: Lingkun Wang Yaochen Xie Boneng Xiao Xuelin He Guanghui Ying Huiyan Zha Chen Yang Xuejin Jin Guilin Li Li Ping Jincheng Wang Qinjie Weng Source Type: research