AKT2 inhibition accelerates the acquisition of phagocytic ability in iPSCs-derived neutrophils

Neutrophils act as the first-line immune players during bacterial infections. Typically, the first leukocytes recruited to inflammatory sites protect humans from pathogens [1]. Despite recent progress in antibacterial and antifungal therapies, the strategy for dealing with risk of severe infections associated with prolonged neutropenia caused by chemotherapy, radiotherapy, cancer, or hematological diseases, needs to be further explored [2 –4]. Some reports demonstrated that the use of granulocyte transfusions (GTX) prevented life-threatening infections in patients with neutropenia induced by chemotherapy or hematopoietic stem cell transplantation, only when high-dose granulocyte transfusion (no less than 0.6 × 109 granulocytes per kilogram) was performed [5].

Source: Experimental Hematology - December 13, 2023 Category: Hematology Authors: Toshiya Hino, Fumio Nakahara, Masashi Miyauchi, Yusuke Ito, Yosuke Masamoto, Ken Morita, Yuki Kagoya, Hirotatsu Kojima, Mineo Kurokawa Tags: Brief Communication Source Type: research