Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants

ConclusionAlmost allCHEK2-associated BCs were ER  + IDC-NST, with most classified as luminal B with or without HER2 overexpression. NGS supported the luminal-like phenotype and confirmedCHEK2 as an oncogenic driver in the majority of cases. Responses to neoadjuvant chemotherapy were variable but mostly incomplete.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research