Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response

In conclusion, we showed that IL-10 binds to its receptor on sensory neurons to downregulate CCL2 and contribute to immunoregulation by reducing the attraction of immune cells by DRG neuron-derived CCL2. This is the first evidence that anti-inflammatory cytokines limit inflammation through direct binding to receptors on sensory neurons. Our data also add to the growing literature that sensory neurons have immunomodulatory functions.PMID:38081433 | DOI:10.1016/j.bbi.2023.12.013

Source: Brain, Behavior, and Immunity - December 11, 2023 Category: Neurology Authors: Sabrina de Souza Jes ús Rosario-Claudio Jaewon Sim Kufreobong E Inyang Andrew Dagenais Karli Monahan Beenhwa Lee Hariharan Ramakrishnan Visha Parmar Matan Geron Gr égory Scherrer Joseph K Folger Geoffroy Laumet Source Type: research