DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition

CONCLUSION: DOT1L overexpression slowed down bone loss and promoted bone formation via the miR-181/KAT2B/SRSF1 axis, thereby alleviating OP development.PMID:38072145 | DOI:10.1016/j.ygeno.2023.110759

Source: Genomics - December 10, 2023 Category: Genetics & Stem Cells Authors: Changsheng Wang Rongsheng Chen Xitian Zhu Xiaobo Zhang Nancheng Lian Source Type: research