Childhood asthma clusters and response to therapy in clinical trials
Conclusions: In this study, we replicated SARP pediatric asthma clusters by using a separate, large clinical trials network. Early-onset/severe-lung function and early-onset/comorbidity clusters were associated with differential and limited response to therapy, respectively. Further prospective study of therapeutic response by cluster could provide new insights into childhood asthma treatment.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Timothy S. Chang, Robert F. Lemanske, David T. Mauger, Anne M. Fitzpatrick, Christine A. Sorkness, Stanley J. Szefler, Ronald E. Gangnon, C. David Page, Daniel J. Jackson, Childhood Asthma Research and Education (CARE) Network Investigators Tags: Asthma and lower airway disease Source Type: research
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