Strategies to Mitigate the Drug-Drug Interaction between Nirmatrelvir/Ritonavir and Tacrolimus in Allogeneic Hematopoietic Stem Cell Transplant Recipients on Azole Antifungals: Results of a Case Series

CONCLUSION: NIM/r-tacrolimus is a serious drug-drug interaction which can be mitigated by early discontinuation of tacrolimus and azole antifungals, close monitoring, and reinitiation of tacrolimus and antifungal 48-72 h after completion of therapy.PMID:38059378 | DOI:10.1159/000534445

Source: Acta Haematologica - December 7, 2023 Category: Hematology Authors: Shawn P Griffin Benjamin Lee Jean Doh Alexander R Paradyse Deepa Jeyakumar Zhaohui Arter Hannah Nam Emily Blodget Julie Smith Anitram Valek Pongthep Vittayawacharin Piyanuch Kongtim Stefan O Ciurea Source Type: research