AIRE is expressed in breast cancer TANs and TAMs to regulate the extrinsic apoptotic pathway and inflammation

In this study we show that AIRE is expressed in human pro-tumor neutrophils. In breast cancer, AIRE was primarily located to tumor associated neutrophils (TANs), and to a lesser extent to tumor associated macrophages (TAMs) and tumor cells. Expression of AIRE in TAN/TAMs, but not in cancer cells, was associated with an adverse prognosis. We show that the functional role for AIRE in neutrophils and macrophages is to regulate expression of immune mediators and the extrinsic apoptotic pathway involving the Fas/TNFR death receptors and Cathepsin G. We here propose that the role for AIRE in TAN/TAMs in breast tumors is to regulate cell death and inflammation, thus promoting tumor progression.PMID:38060995 | DOI:10.1093/jleuko/qiad152

Source: Journal of Leukocyte Biology - December 7, 2023 Category: Hematology Authors: Eva K ällberg Meliha Mehmeti-Ajradini Frida Bj örk Gunnarsdottir Marcus G öransson Caroline Bergenfelz Roni Allaoui Fredriksson Catharina Hagerling Martin E Johansson Charlotte Welinder Karin Jirstr öm Karin Leandersson Source Type: research