Evaluation of dermal toxicity and toxicokinetics of povidone ‑iodine in Göttingen minipigs

CONCLUSION: Once-daily dermal application of 7.5% and 10% PVP-I for up to 39 weeks was safe and well tolerated in Göttingen Minipigs® and was not associated with skin irritation, thyroid dysfunction, or endocrine disruption. As the anatomy and physiology of the minipig skin closely resembles that of human skin, the findings of this study suggest that 7.5% and 10% PVP-I may be translated into antimicrobial benefits for humans without the risk of endocrine disruption.PMID:38061611 | DOI:10.1016/j.taap.2023.116783
Source: Toxicology and Applied Pharmacology - Category: Toxicology Authors: Source Type: research