Compatibility of nanoparticulate iv iron with all-in-one parenteral nutrition admixtures tested by ICP-MS

Rationale: Free, polyvalent iron (Fe) shows redox reactivity, toxic radical formation, and incompatibilities. Fe deficiency is a prevalent condition often requiring IV Fe infusion. When parenteral nutrition (PN) is also needed, as in neonates or IBD patients, combined treatment is limited due to lack of stability and compatibility. Selected IV Fe nanoparticles could overcome this issue. The aim of this project was to investigate stability and compatibility of different Fe nanoparticles admixed to all-in-one (AiO) PN admixtures at therapeutic daily Fe doses of 200 mg.

Source: Clinical Nutrition ESPEN - December 1, 2023 Category: Nutrition Authors: V.V. Huwiler, C. Saxer, P. Neyer, K.A. Sch önenberger, Z. Stanga, A. Hammerer-Lercher, S. Mühlebach Source Type: research