Characterization of human engraftment and hemophagocytic lymphohistiocytosis in NSG-SGM3 neonate mice engrafted with purified CD34+ hematopoietic stem cells

“Humanized’ mice have been utilized as a novel approach for studies of basic human immunology, immuno-oncology, study of hematological disorders, infectious diseases, and autoimmunity. NSG (NOD.CB17-Prkdcscid Il2rgtm1Wj1/Sz) mice are commonly used recipients for human HSC1, 2. In addition to bei ng homozygous for the severe combined immunodeficiency (SCID) mutation, NSG mice also express a disrupted murine Interleukin (IL)2-receptor common γ chain which prevents B, T and NK cell development, along with many other immune lineages3.

Source: Experimental Hematology - December 3, 2023 Category: Hematology Authors: O'Brien Liam, Walpole Carina, Leal-Rojas Ingrid, Shatunova Svetlana, Moore Andrew, Ingrid G Winkler, Guillerey Camille, Kristen J Radford Tags: Brief Communication Source Type: research