The bladder microbiota is not significantly altered by intravesical BCG therapy

CONCLUSION: We were unable to identify markers of bladder microbiota dysbiosis among male NMIBC patients. Moreover, we demonstrated for the first time using longitudinally collected samples that BCG cannot persist in the bladder microbiota nor significantly alter its diversity and composition. The associations found between bladder microbes and BCG efficacy highlight the potential of microbial-based therapeutic and risk-stratification strategies in the intermediate/high-risk NMIBC setting.PMID:38030469 | DOI:10.1016/j.urolonc.2023.11.003

Source: Urologic Oncology - November 29, 2023 Category: Urology & Nephrology Authors: Vitor Heidrich Antonio C H Mariotti Lilian T Inoue Elisangela M Coser Ernande X Dos Santos Hugo D B Dos Santos Paula F Asprino Fabiana Bettoni Guilherme A P Costa Diogo A Bastos Denis L Jardim Marco A Arap Anamaria A Camargo Source Type: research